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Taking into account the frequency of alterations in known genes involved in PI3K-AKT-mTOR pathway activation, applying PI3K pathway blockers could possibly be an effective target strategy in MM patients

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It is of some interest that realgar, a polymorph of arsenic sulphide (As 4 S 4 ), and cinnabar (mercury sulphide) found an ethno-pharmacological use in Chinese medicine [193,194]